Szelies B, Mielke R, Grond M, Heiss W D
Max-Planck-Institut für neurologische Forschung and Neurologische Universitätsklinik, Cologne, Germany.
J Neurol Sci. 1995 May;130(1):77-81. doi: 10.1016/0022-510x(95)00006-n.
In 45 patients (aged 48-85 years) with probable Alzheimer's disease (AD) according to current research criteria (NINCDS-ADRDA) with different stages of dementia severity (Mini Mental Status Examination (MMSE) 7-27) the auditory evoked P300 waves were mapped and regional cerebral metabolic rates of glucose were measured by positron emission tomography of 2-[18F]fluoro-2-deoxy-D-glucose. Age adjusted P300 latency was significantly correlated to dementia severity (r = -0.33, p = 0.028), but no significant relationships were found for P300 amplitudes. Dependencies existed among cortical glucose metabolic rates and MMSE with the highest correlation coefficient for the metabolic ratio of regions typically affected and non-affected in AD (r = 0.75, p = 0.0001). A significant correlation was also calculated between P300 latency and metabolic ratio (r = -0.44, p = 0.002), but no relationships were observed among P300 amplitudes and glucose metabolic rates of individual brain regions. These results indicate that P300 latency and metabolic rates but not P300 amplitudes qualify as measures of severity in AD. The lack of regional correlations among P300 amplitudes and glucose metabolism is not consistent with a cortical contribution to P300 generation.
根据当前研究标准（NINCDS-ADRDA），选取45例可能患有阿尔茨海默病（AD）的患者（年龄48 - 85岁），其痴呆严重程度处于不同阶段（简易精神状态检查表（MMSE）评分为7 - 27分），对他们进行听觉诱发电位P300波图谱分析，并通过2 - [18F]氟 - 2 - 脱氧 - D - 葡萄糖正电子发射断层扫描测量局部脑葡萄糖代谢率。年龄校正后的P300潜伏期与痴呆严重程度显著相关（r = -0.33，p = 0.028），但未发现P300波幅有显著相关性。皮质葡萄糖代谢率与MMSE之间存在相关性，在AD中典型受累和未受累区域的代谢率相关性最高（r = 0.75，p = 0.0001）。还计算出P300潜伏期与代谢率之间存在显著相关性（r = -0.44，p = 0.002），但未观察到P300波幅与各个脑区葡萄糖代谢率之间的关系。这些结果表明，P300潜伏期和代谢率而非P300波幅可作为AD严重程度的衡量指标。P300波幅与葡萄糖代谢之间缺乏区域相关性，这与皮质对P300产生的贡献不一致。
