Mielke R, Kessler J, Fink G, Herholz K, Heiss W D
Max-Planck-Institut für neurologische Forschung, Köln.
Int J Neurosci. 1995 May;82(1-2):1-9. doi: 10.3109/00207459508994285.
The relation between visual impairment and regional cerebral metabolic rate of glucose (rCMRGl) was studied in 31 patients with probable Alzheimer's disease (AD) by using positron emission tomography with 18F-2-fluoro-2-deoxy-D-glucose. To exclude any precortical cause of visual dysfunction only patients were included who had amplitudes and latencies of visually evoked potentials (flash and pattern reversal) within the normal range. Visual information processing was evaluated psychometrically by a fragmented picture test (FPT), which is a combined perception (identification score) and memory (reidentification score) task and refers to Gollin's incomplete pictures. The identification and reidentification scores were significantly worse than in normals. Reductions of the rCMRGl in the primary visual fields, and in the secondary visual fields were found. A significant partial correlation with adjustment for age between the reidentification score of the FPT and the rCMRGl of the secondary visual fields (r = -.39, p < .05) in AD patients was found, indicating involvement of the secondary visual cortex in the pathological changes in AD.
采用18F-2-氟-2-脱氧-D-葡萄糖正电子发射断层扫描技术，对31例可能患有阿尔茨海默病（AD）的患者的视力损害与局部脑葡萄糖代谢率（rCMRGl）之间的关系进行了研究。为排除任何皮质前视觉功能障碍的原因，仅纳入视觉诱发电位（闪光和图形翻转）的波幅和潜伏期在正常范围内的患者。通过碎片化图片测试（FPT）对视觉信息处理进行心理测量评估，这是一项综合感知（识别分数）和记忆（再识别分数）的任务，参考了戈林不完整图片。AD患者的识别和再识别分数显著低于正常人。研究发现，初级视场和次级视场的rCMRGl均降低。在AD患者中，FPT的再识别分数与次级视场的rCMRGl之间存在显著的年龄校正偏相关（r = -0.39，p < 0.05），表明次级视皮层参与了AD的病理变化。
