Shonk T, Ross B D
Magnetic Resonance Spectroscopy Unit, Huntington Medical Research Institutes, Pasadena, CA 91105, USA.
Magn Reson Med. 1995 Jun;33(6):858-61. doi: 10.1002/mrm.1910330619.
The purpose of this study was to determine cerebral myo-inositol (mI) in adults with Down syndrome (DS), and to trace the chronobiology of DS to Alzheimer disease (AD). AD has characteristic neuropathology of neurofibrillary plaques and tangles; indirect evidence links this to earlier deposition of beta-amyloid. Elevated mI, which distinguishes AD from other common dementias, is also elevated in 23 young patients who have DS without dementia. In one patient who has DS with dementia, mI is elevated and N-acetylaspartate (NAA) decreased. The similarity to AD is striking and may suggest a progressive neurochemical disorder in which elevation of mI precede loss of NAA in both AD and DS.
本研究的目的是测定唐氏综合征（DS）成人患者大脑中的肌醇（mI），并追踪DS向阿尔茨海默病（AD）发展的时间生物学过程。AD具有神经原纤维斑块和缠结的特征性神经病理学表现；间接证据将此与β-淀粉样蛋白的早期沉积联系起来。mI升高是AD区别于其他常见痴呆症的特征，在23名无痴呆症的年轻DS患者中mI也升高。在一名患有DS且伴有痴呆症的患者中，mI升高而N-乙酰天门冬氨酸（NAA）降低。与AD的相似性非常显著，这可能提示存在一种进行性神经化学紊乱，在AD和DS中mI升高均先于NAA的丧失。
