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Superoxide dismutase activity of the captopril-iron complex.

作者信息

Jay D, Cuella A, Jay E

机构信息

Department of Biochemistry, State University of New York (HSCB) 11203-2098, USA.

出版信息

Mol Cell Biochem. 1995 May 10;146(1):45-7. doi: 10.1007/BF00926880.

DOI:10.1007/BF00926880
PMID:7651376
Abstract

With an assay that generates superoxide anion radicals without the intervention of metal ions we investigated the antioxidant properties of captopril, an angiotensin-converting enzyme inhibitor with a sulfhydryl group. Under these conditions, increasing concentrations of the drug were seen not to scavenge O.-2 directly. However, a combination of captopril and iron could bring about the breakdown of the superoxide anion; a result that may help to understand the free radical-scavenging properties of captopril.

摘要

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Angiotensin-converting enzyme inhibitor captopril prevents activation-induced apoptosis by interfering with T cell activation signals.

本文引用的文献

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Superoxide-dependent formation of hydroxyl radicals from ferric-complexes and hydrogen peroxide: an evaluation of fourteen iron chelators.超氧化物依赖的铁络合物和过氧化氢生成羟基自由基的过程：十四种铁螯合剂的评估
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