Cruz O A, Matkovich L
Anheuser-Busch Eye Institute, St Louis University School of Medicine, Mo., USA.
Ophthalmic Surg. 1995 May-Jun;26(3):237-40.
The effect of intraoperative topical exposure of mitomycin-C (MMC) on muscle reattachment and scarring in strabismus surgery was prospectively investigated in the rabbit by performing bilateral recession surgery in which one eye was treated with topical MMC (0.2 mg/mL) and the other eye served as the control. One week postoperatively, in random, masked fashion, the severity of postoperative adhesions was rated lower in the MMC-treated eyes. Also, histology demonstrated decreased fibrosis in the muscle reattachment sites in the MMC-treated eyes. The muscle tension in the reattached muscles was greater than 100 g in all of the eyes. This preliminary study indicates that topical MMC exposure may inhibit scarring in strabismus surgery without inhibiting muscle reattachment or causing other obvious adverse effects.
通过在兔身上进行双侧内直肌后徙手术，前瞻性地研究术中局部应用丝裂霉素C（MMC）对斜视手术中肌肉重新附着和瘢痕形成的影响。手术中，一只眼局部应用MMC（0.2mg/mL），另一只眼作为对照。术后一周，以随机、盲法评估，MMC治疗眼的术后粘连严重程度较低。此外，组织学显示MMC治疗眼的肌肉重新附着部位纤维化减少。所有眼中重新附着肌肉的肌张力均大于100g。这项初步研究表明，局部应用MMC可能抑制斜视手术中的瘢痕形成，而不会抑制肌肉重新附着或引起其他明显的不良反应。
