Oh S O, Chang B L, Lee J
Department of Opthalmology, College of Medicine, Chungbuk National University, Cheongju, Korea.
Korean J Ophthalmol. 1995 Jun;9(1):51-8. doi: 10.3341/kjo.1995.9.1.51.
In adjustable strabismus surgery, a satisfactory final result would be achieved with delayed adjustment. However, the postoperative adhesions following strabismus surgery make delayed adjustment impossible. We evaluated the efficacy of mitomycin C in reducing the severity of postoperative adhesions following strabismus surgery and in delaying the time adjustment after surgery. Experimental rabbits underwent a hang-back recession procedure in the superior rectus muscle. A topical application of mitomycin C was made between the conjunctiva and the sclera for 5 minutes during the operation. We then studied the possible time of delayed adjustment and estimated the minimal forces required for the adjustment. The topical application of 0.1 mg/ml mitomycin C between the conjunctiva and sclera allowed for a 2-week delayed adjustment after surgery, and 0.2 mg/ml mitomycin C prevented the adhesions between these tissues and the muscle 5 weeks after surgery. These results suggest that topical mitomycin C may enhance the success rate of strabismus surgery with delayed adjustment and reduce postoperative adhesions.
在可调节性斜视手术中，延迟调整可取得令人满意的最终效果。然而，斜视手术后的术后粘连使得延迟调整无法实现。我们评估了丝裂霉素C在减轻斜视手术后术后粘连严重程度以及延迟术后调整时间方面的疗效。实验兔的上直肌进行了后徙悬吊手术。术中在结膜与巩膜之间局部应用丝裂霉素C 5分钟。然后我们研究了延迟调整的可能时间，并估计了调整所需的最小力量。在结膜与巩膜之间局部应用0.1 mg/ml丝裂霉素C可使术后延迟2周进行调整，而0.2 mg/ml丝裂霉素C可在术后5周防止这些组织与肌肉之间发生粘连。这些结果表明，局部应用丝裂霉素C可能会提高斜视手术延迟调整的成功率，并减少术后粘连。
