多种DNA结合蛋白和多聚体蛋白含有组蛋白折叠基序。
A variety of DNA-binding and multimeric proteins contain the histone fold motif.
作者信息
Baxevanis A D, Arents G, Moudrianakis E N, Landsman D
机构信息
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA.
出版信息
Nucleic Acids Res. 1995 Jul 25;23(14):2685-91. doi: 10.1093/nar/23.14.2685.
Abstract
The histone fold motif has previously been identified as a structural feature common to all four core histones and is involved in both histone-histone and histone-DNA interactions. Through the use of a novel motif searching method, a group of proteins containing the histone fold motif has been established. The proteins in this group are involved in a wide variety of functions related mostly to DNA metabolism. Most of these proteins engage in protein-protein or protein-DNA interactions, as do their core histone counterparts. Among these, CCAAT-specific transcription factor CBF and its yeast homologue HAP are two examples of multimeric complexes with different component subunits that contain the histone fold motif. The histone fold proteins are distantly related, with a relatively small degree of absolute sequence similarity. It is proposed that these proteins may share a similar three-dimensional conformation despite the lack of significant sequence similarity.
摘要
组蛋白折叠基序先前已被确定为所有四种核心组蛋白共有的结构特征，并且参与组蛋白-组蛋白以及组蛋白-DNA相互作用。通过使用一种新颖的基序搜索方法，已建立了一组包含组蛋白折叠基序的蛋白质。该组中的蛋白质参与了多种主要与DNA代谢相关的功能。这些蛋白质中的大多数都像其核心组蛋白对应物一样参与蛋白质-蛋白质或蛋白质-DNA相互作用。其中，CCAAT特异性转录因子CBF及其酵母同源物HAP是具有不同组成亚基的多聚体复合物的两个例子，这些亚基包含组蛋白折叠基序。组蛋白折叠蛋白之间关系较远，绝对序列相似性程度相对较小。有人提出，尽管缺乏明显的序列相似性，但这些蛋白质可能共享相似的三维构象。
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本文引用的文献
1
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Plant Physiol. 1992 Dec;100(4):1633-9. doi: 10.1104/pp.100.4.1633.
2
An empirical energy function for threading protein sequence through the folding motif.一种用于将蛋白质序列穿入折叠基序的经验能量函数。
Proteins. 1993 May;16(1):92-112. doi: 10.1002/prot.340160110.
3
Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2.人类 Sos1：一种与GRB2结合的Ras鸟嘌呤核苷酸交换因子。
Science. 1993 May 28;260(5112):1338-43. doi: 10.1126/science.8493579.
4
Nucleotide sequence of a gene encoding a histone-like protein in the archaeon Methanococcus voltae.沃氏甲烷球菌中编码一种组蛋白样蛋白的基因的核苷酸序列。
Nucleic Acids Res. 1993 Mar 25;21(6):1491. doi: 10.1093/nar/21.6.1491.
5
ALSCRIPT: a tool to format multiple sequence alignments.ALSCRIPT：一种用于格式化多序列比对的工具。
Protein Eng. 1993 Jan;6(1):37-40. doi: 10.1093/protein/6.1.37.
6
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7
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8
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10
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