Damotte D, Le Tourneau A, Audouin J, Duval C, Martin-Bastenaire F, Villain O, Delobelle-Deroide A, Diebold J
Service Central Jacques-Delarue d'Anatomie et de Cytologie Pathologiques, Hotel-Dieu, France.
Pathol Res Pract. 1995 Feb;191(1):8-15. doi: 10.1016/s0344-0338(11)80916-7.
We report in 4 patients the rare association of Hodgkin's disease and high grade B malignant lymphoma. In 2 cases, both tumours were disclosed at the same time but in different tissues from the same region. In the 2 other patients, the second tumour was found 11 months and 12 months after the first respectively. In all cases Hodgkin's disease was of the nodular sclerosing type, the tumour cells expressing CD 30 and CD 15. The high grade lymphomas were of the polymorphic centroblastic (large non cleaved) type and expressed the B markers. One (case 4) was secondary to a follicular lymphoma. In 2 cases (2 and 4) the search for a latent EBV infection was negative in both tumours. In case 1, only the Reed-Sternberg cells were positive with both techniques. Such an association is different from so-called composite lymphomas, and can be called "discordant lymphoma". Different related conditions are discussed. This association is distinct from lymphomas or Hodgkin's disease complicating the treatment of Hodgkin's disease or malignant lymphomas.
我们报告了4例霍奇金病与高级别B细胞恶性淋巴瘤的罕见关联。在2例中，两种肿瘤同时被发现，但位于同一区域的不同组织。在另外2例患者中，第二种肿瘤分别在第一种肿瘤发现后的11个月和12个月被发现。在所有病例中，霍奇金病均为结节硬化型，肿瘤细胞表达CD 30和CD 15。高级别淋巴瘤为多形性中心母细胞（大无裂）型，并表达B细胞标志物。其中1例（病例4）继发于滤泡性淋巴瘤。在2例（病例2和4）中，两种肿瘤的潜伏性EBV感染检测均为阴性。在病例1中，仅里德-施特恩伯格细胞在两种检测技术中均呈阳性。这种关联不同于所谓的复合淋巴瘤，可称为“不一致性淋巴瘤”。文中讨论了不同的相关情况。这种关联有别于霍奇金病或恶性淋巴瘤治疗过程中并发的淋巴瘤或霍奇金病。
