Wiis J, Sheller J P
infektionsimmunologisk afdeling, Statens Seruminstitut, København.
Ugeskr Laeger. 1995 Jul 17;157(29):4134-6.
In Botswana in southern Africa, an area with a high prevalence of syphilis, non-venereal treponematoses used to be prevalent. In the present study sera from 136 children (0-18 years) were analysed to evaluate whether infection with non-venereal treponematoses during childhood could explain the high prevalence of treponemal seropositivity found in adults. In the age group 0-14 years, seropositivity was demonstrated in one (1%) of 87 children, compared to 10 (20%) of 49 children in the age group 15-18 years, a statistically significantly higher prevalence. All cases of seropositivity were due to active infection. The local laboratory in Botswana failed to diagnose four (36%) of the 11 cases of active syphilis when the VDRL-test alone was used. We conclude that no serological indication of non-venereal treponematoses were found in the examined children, and that syphilis was the cause of the high prevalence of treponemal infection among the sexually active adults in Botswana. It is recommended that both the VDRL-test and the TPHA-test are used in screening for syphilis in Botswana. Sexually transmitted disease-campaigns directed at the youth in Botswana should have high priorities.
在非洲南部的博茨瓦纳，梅毒高发地区曾是非性病性梅毒螺旋体病的流行区。在本研究中，对136名儿童（0至18岁）的血清进行分析，以评估儿童期非性病性梅毒螺旋体病感染是否能解释在成人中发现的梅毒螺旋体血清学阳性高患病率。在0至14岁年龄组中，87名儿童中有1名（1%）血清学呈阳性，而在15至18岁年龄组的49名儿童中有10名（20%）呈阳性，患病率在统计学上显著更高。所有血清学阳性病例均为活动性感染。当仅使用性病研究实验室玻片试验（VDRL试验）时，博茨瓦纳当地实验室未能诊断出11例活动性梅毒病例中的4例（36%）。我们得出结论，在所检查的儿童中未发现非性病性梅毒螺旋体病的血清学迹象，并且梅毒是博茨瓦纳性活跃成年人中梅毒螺旋体感染高患病率的原因。建议在博茨瓦纳梅毒筛查中同时使用VDRL试验和梅毒螺旋体血细胞凝集试验（TPHA试验）。针对博茨瓦纳青年的性传播疾病防治运动应具有高度优先性。
