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Markers of osteoarthritis: a review of the literature.

作者信息

Rørvik A M, Grøndahl A M

机构信息

Norwegian College of Veterinary Medicine, Department of Small Animal Clinical Sciences, Oslo.

出版信息

Vet Surg. 1995 May-Jun;24(3):255-62. doi: 10.1111/j.1532-950x.1995.tb01327.x.

DOI:10.1111/j.1532-950x.1995.tb01327.x
PMID:7653041
Abstract

There may be a great potential in the use of diagnostic "markers" of osteoarthritis in synovial fluid to diagnose the disease in an earlier stage and perhaps assess the severity of the disease and monitor the effect of a treatment. In the present study, potential markers are characterized, discussed, and grouped according to the latest knowledge on the etiology, pathogenesis, and pathology of osteoarthritis. They are grouped according to their origin as either cartilage degradation products, or related to the mechanisms of cartilage degradation, or related to chrondrocytic anabolic activity during disease, or related to genetic disorders. Also potential markers that have not yet been studied clinically or experimentally are discussed. Examples of the progress that has been made in human medicine approaching reliable diagnostic markers that should also be tried in veterinary medicine are described.

摘要

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Myeloperoxidase and chlorinated peptides in osteoarthritis: potential biomarkers of the disease.
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