Rørvik A M, Teige J
Department of Small Animal Clinical Sciences, Norwegian College of Veterinary Medicine, Oslo, Norway.
Acta Vet Scand. 1996;37(3):265-72. doi: 10.1186/BF03548093.
Thirteen young, castrated male goats had instability of one stifle (knee joint) created by surgical transection of the cranial cruciate ligament, but did not develop any signs of osteoarthritis (OA) in treated joints when confined in limited space for 8 months. At the end of the experiment, the instability in the stifles had not improved, the joints were normal at radiographic examination, there were no signs of inflammation in the synovial membrane or joint capsule, and fibrosis in these tissues was not evident. The articular cartilage was normal both visually and histologically. This may indicate that the young age of the goats and the restricted physical activity on soft floor had prevented the expected development of OA in the experimentally operated joints. Synovial fluid volumes and proteoglycan concentration were measured in the treated and control joints in 6 of the goats. There seemed to be increased quantity of the proteoglycan aggrecan in the synovial fluid from the treated joints compared to the contralateral joints throughout the course of this study. It was concluded that the turnover of aggrecan in the articular cartilage of the treated joints may have been increased.
13只年轻的去势公山羊通过手术切断颅交叉韧带造成一侧膝关节（ stifle ）不稳定，但在有限空间内饲养8个月期间，治疗关节未出现任何骨关节炎（OA）迹象。实验结束时，膝关节的不稳定并未改善，X线检查关节正常，滑膜或关节囊无炎症迹象，这些组织中也未明显出现纤维化。关节软骨在视觉和组织学上均正常。这可能表明山羊的年轻以及在柔软地面上受限的身体活动阻止了实验操作关节中预期的OA发展。对6只山羊的治疗关节和对照关节的滑液体积和蛋白聚糖浓度进行了测量。在本研究过程中，与对侧关节相比，治疗关节滑液中蛋白聚糖聚集蛋白聚糖的量似乎有所增加。得出的结论是，治疗关节的关节软骨中聚集蛋白聚糖的周转可能增加了。
