Melínova L, Hermanská Z, Halíková J, Dienstbier Z, Vacková B, Zámecník J, Skala E
Pneumologická klinika 1. LF UK, Praha.
Vnitr Lek. 1995 May;41(5):307-12.
The impact of prognostic factors for survival was analyzed in a group of 337 patients with Hodgkin's disease. The analysis of survival of patients comprised a total of 13 indicators: histological types LP, NS, MC, LD, clinical stages I, II, III, IV, E lesions, symptomatology A, B, size of the mediastinal tumour (index), age at onset of disease and sex. Cumulative survival of 5, 10, and 20 years in the whole group is 83%, 80% and 72% resp. A first complete remission was achieved by 284 patients, cumulative survival without the disease is 79% after 5 and 73% after 10 years since completion of primary treatment. A significantly adverse effect on the prognosis of survival is exerted by symptomatology B, a large mediastinal tumour, advanced age, clinical stage IV and III. Most important are the first two factors mentioned. An adverse prognostic factor for survival without disease is male sex. The therapeutic protocol was repeatedly modified in the course of 25 years with regard to prognostic patient groups.
对337例霍奇金病患者的生存预后因素进行了分析。患者生存分析共包括13项指标：组织学类型LP、NS、MC、LD，临床分期I、II、III、IV，E病变，症状A、B，纵隔肿瘤大小（指数），发病年龄及性别。全组5年、10年和20年的累积生存率分别为83%、80%和72%。284例患者实现了首次完全缓解，自初次治疗结束后5年无病累积生存率为79%，10年后为73%。症状B、大纵隔肿瘤、高龄、临床分期IV和III对生存预后有显著不良影响。提及的前两个因素最为重要。男性性别是无病生存的不良预后因素。在25年的过程中，针对预后患者群体对治疗方案进行了多次修改。
