Carlsten J, Bjurström S, Häggendal J, Jönsson L
Department of Clinical Radiology and Pathology, Faculty of Veterinary Medicine, Swedish University of Agricultural Sciences, Uppsala.
Zentralbl Veterinarmed A. 1994 Dec;41(10):722-30. doi: 10.1111/j.1439-0442.1994.tb00142.x.
Pigs, crossbreeds of Swedish Landrace and Yorkshire, about 6 months old and susceptible to develop malignant hyperthermia when exposed to halothane, were subjected to a 12-min experimental stress provoked by the myorelaxant succinylcholine. The experimental pigs were pre-treated before the stress: five were given propranolol for one week, six were given alpha-tocopherol (vitamin E) combined with selenium for 11 days, and five pigs were pre-treated with zinc (ZnSO4) for 1 month. A total of 12 untreated, stress-susceptible pigs served as controls. The blood levels of noradrenaline and adrenaline recorded during the stress were significantly reduced in the groups pre-treated with propranolol or alpha-tocopherol combined with selenium. The results show significant reduction of myocardial necrosis by beta-adrenoceptor-blocking agents and free-radical scavengers during stress-induced increased sympathetic activity.
选用瑞典长白猪与约克夏猪的杂交种猪，约6月龄，接触氟烷时易发生恶性高热，使其接受由肌肉松弛剂琥珀酰胆碱引发的12分钟实验性应激。实验猪在应激前进行预处理：5只猪给予普萘洛尔一周，6只猪给予α-生育酚（维生素E）联合硒11天，5只猪用锌（硫酸锌）预处理1个月。共有12只未经处理、对应激敏感的猪作为对照。在应激期间记录的去甲肾上腺素和肾上腺素的血药浓度，在给予普萘洛尔或α-生育酚联合硒预处理的组中显著降低。结果表明，在应激诱导的交感神经活动增加期间，β-肾上腺素能受体阻滞剂和自由基清除剂可显著减少心肌坏死。
