Blatteis C M
J Appl Physiol. 1976 Jan;40(1):29-34. doi: 10.1152/jappl.1976.40.1.29.
The pyrogenic response of adult, unanesthetized guinea pigs to 2 mug/kg iv of Salmonella enteritidis endotoxin was measured at 27 and 7 degrees C ambient temperatures, both before and after an 8-wk exposure to 7 degrees C. There were no significant differences between the onset, maximum height, and total duration of the fevers produced before and after cold acclimation in both thermal environments. However, in 27 degrees C, before cold acclimation, fever production was associated with vigorous shivering activity; two temperature maxima typically developed. After cold acclimation, visible shivering was not detectable during pyrogenesis; moreover, only a single maximum occurred, culminating during the interval between the two rises previously. In 7 degrees C, shivering occurred in both the non-cold- and cold-acclimated endotoxin-treated guinea pigs, but the increase in oxygen consumption was significantly greater in the latter. These results indicated, therefore, that nonshivering (NST) replaces shivering thermogenesis (ST) in a thermoneutral, while ST is added onto NST in a cold, environment in cold-acclimated guinea pigs in supplying the necessary heat for fever production, and that these effects involve alterations in the character of the febrile course.
在27℃和7℃的环境温度下，分别于成年未麻醉豚鼠8周暴露于7℃环境之前和之后，测量其对静脉注射2μg/kg肠炎沙门氏菌内毒素的发热反应。在这两种热环境中，冷适应前后产生的发热在起始时间、最高体温和总持续时间方面均无显著差异。然而，在27℃环境下，冷适应前，发热与剧烈颤抖活动有关，通常会出现两个体温峰值。冷适应后，致热过程中未检测到明显颤抖；此外，仅出现一个峰值，且出现在之前两次体温上升之间的时间段内。在7℃环境下，未冷适应和冷适应的内毒素处理豚鼠均出现颤抖，但后者的耗氧量增加显著更大。因此，这些结果表明，在热中性环境中，非颤抖性产热（NST）取代了颤抖性产热（ST），而在寒冷环境中，冷适应豚鼠的ST叠加在NST之上，为发热产生提供必要的热量，并且这些效应涉及发热过程特征的改变。
