Jinnouchi K, Tomiyama S, Pawankar R
Department of Otolaryngology, Nippon Medical School, Tokyo, Japan.
Acta Otolaryngol. 1995 May;115(3):400-4. doi: 10.3109/00016489509139337.
Endothelin-1 (ET-1), originally characterized as a 21-residue vasoconstrictor peptide from endothelial cells, has been reported to act as a local hormonal regulator of pressure, fluid, ions as well as neuropeptides. The present study investigated the distribution of ET-1 in the endolymphatic sac and duct of normal guinea pigs, by immunohistochemistry. ET-1 like activity was identified in the epithelial cells and subepithelial connective tissue of the endolymphatic sac and duct. No significant difference was seen in the intermediate and proximal portions. These findings suggest that ET-1 may play an important role in the regulation of inner ear pressure, fluid volume, and ion balance.
内皮素-1（ET-1）最初被鉴定为一种来自内皮细胞的由21个氨基酸残基组成的血管收缩肽，据报道它可作为压力、液体、离子以及神经肽的局部激素调节因子。本研究通过免疫组织化学方法，调查了正常豚鼠内淋巴囊和内淋巴管中ET-1的分布情况。在内淋巴囊和内淋巴管的上皮细胞及上皮下结缔组织中发现了ET-1样活性。在中间部分和近端部分未观察到显著差异。这些发现表明，ET-1可能在调节内耳压力、液体容量和离子平衡方面发挥重要作用。
