Jinnouchi K, Tomiyama S, Pawankar R, Yagi T
Department of Otolaryngology, Nippon Medical School, Tokyo, Japan.
Acta Otolaryngol Suppl. 1997;528:10-4.
Endothelin (ET), originally characterized as a 21-residue vasoconstrictor peptide from endothelial cells, has been reported to act as a local hormonal regulator of pressure, fluid, ions, and neurotransduction. Our previous studies suggested an important role of ET-1 in the inner ear. The present study investigated the time kinetics of ET-1 in the epithelium of the endolymphatic sac (ES) of guinea pigs and its relation to the development of endolymphatic hydrops (EH) following locally mounted secondary immune reaction. In the duration between 12 h and day 1, ET-1-like activity completely disappeared from the epithelium of the ES and was associated with the accumulation of inflammatory cells in the ES and a rapid development of EH. On day 7, ET-1-like activity recovered as a consequence of the decrease of inflammatory cells and reduction of EH. These findings suggest that ET-1 may play an important role as one of the regulators maintaining the fluid balance.
内皮素（ET）最初被鉴定为一种来自内皮细胞的由21个氨基酸残基组成的血管收缩肽，据报道它可作为压力、液体、离子和神经传导的局部激素调节因子。我们之前的研究表明ET-1在内耳中起重要作用。本研究调查了豚鼠内淋巴囊（ES）上皮中ET-1的时间动力学及其与局部继发性免疫反应后内淋巴积水（EH）发展的关系。在12小时至第1天期间，ES上皮中的ET-1样活性完全消失，这与ES中炎症细胞的积聚以及EH的快速发展有关。在第7天，由于炎症细胞减少和EH减轻，ET-1样活性恢复。这些发现表明，ET-1可能作为维持液体平衡的调节因子之一发挥重要作用。
