Moss H B, Vanyukov M, Majumder P P, Kirisci L, Tarter R E
Center for Education and Drug Abuse Research, University of Pittsburgh School of Medicine, PA 15213, USA.
Addict Behav. 1995 May-Jun;20(3):345-58. doi: 10.1016/0306-4603(94)00077-c.
In order to better understand the transgeneration liability for a substance abuse disorder, we investigated the impact of parental and familial substance abuse disorders on prepubertal boys. Specifically, the influence of each parent's substance abuse history and the effects of significant family aggregation of substance abuse disorders were tested as predictors of the child's behavioral disposition, IQ, and school achievement scores, while controlling for socioeconomic status (SES). Sons of substance abusing fathers were found to have higher externalizing and internalizing problem-behavior scores, lower IQ scores, and lower school achievement scores. Internalizing and externalizing problem-behavior scores were most strongly associated with bilineal parental substance abuse, whereas SES and paternal substance abuse were most strongly associated with IQ and school performance scores. The results are compatible with the hypothesis that although paternal substance abuse has an adverse impact on the son's functioning, bilineal parental substance abuse is associated with the greatest behavioral deviancy among prepubertal males and is associated with a greater liability for substance abuse.
为了更好地理解物质使用障碍的跨代易感性，我们研究了父母及家族性物质使用障碍对青春期前男孩的影响。具体而言，在控制社会经济地位（SES）的同时，测试了每位父母的物质使用史的影响以及物质使用障碍显著家族聚集性的影响，作为儿童行为倾向、智商和学业成绩得分的预测因素。发现有物质使用障碍父亲的儿子具有更高的外化和内化问题行为得分、更低的智商得分以及更低的学业成绩得分。内化和外化问题行为得分与双亲物质使用障碍的关联最为紧密，而SES和父亲物质使用障碍与智商和学业成绩得分的关联最为紧密。这些结果与以下假设相符：尽管父亲物质使用障碍对儿子的功能有不利影响，但双亲物质使用障碍与青春期前男性中最大程度的行为偏差相关，并且与物质使用障碍的更高易感性相关。
