Malison R T, Best S E, van Dyck C H, McCance E F, Wallace E A, Laruelle M, Baldwin R M, Seibyl J P, Price L H, Kosten T R, Innis R B
Department of Psychiatry, Yale University School of Medicine, New Haven, Conn., USA.
Am J Psychiatry. 1998 Jun;155(6):832-4. doi: 10.1176/ajp.155.6.832.
The authors examined whether striatal dopamine transporters were altered in acutely (96 hours or less) abstinent cocaine-abusing subjects, as suggested by postmortem studies.
[123I] beta-CIT and single photon emission computed tomography were used to assess striatal dopamine transporter levels in 28 cocaine-abusing subjects and 24 comparison subjects matched as a group for age and gender.
Results showed a significant (approximately 20%) elevation in striatal V3" values in acutely abstinent cocaine-abusing subjects relative to comparison subjects. An inverse correlation between dopamine transporter level and Hamilton Depression Rating Scale score was also observed.
These findings indicate more modest elevations in striatal dopamine transporters in cocaine-abusing subjects than noted in previous postmortem reports and suggest a possible relationship between cocaine-related depression and dopamine transporter binding.
正如尸检研究所表明的，作者们探究了急性（96小时或更短时间）戒毒的可卡因滥用者纹状体多巴胺转运体是否发生改变。
使用[123I]β-CIT和单光子发射计算机断层扫描来评估28名可卡因滥用者和24名年龄及性别匹配的对照者的纹状体多巴胺转运体水平。
结果显示，与对照者相比，急性戒毒的可卡因滥用者纹状体V3”值显著升高（约20%）。还观察到多巴胺转运体水平与汉密尔顿抑郁量表评分之间呈负相关。
这些发现表明，可卡因滥用者纹状体多巴胺转运体的升高幅度比之前尸检报告中指出的要小，并提示可卡因相关抑郁与多巴胺转运体结合之间可能存在关联。
