舍曲林治疗社交恐惧症：一项双盲、安慰剂对照交叉研究。
Sertraline for social phobia: a double-blind, placebo-controlled crossover study.
作者信息
Katzelnick D J, Kobak K A, Greist J H, Jefferson J W, Mantle J M, Serlin R C
机构信息
Foundation for Health, Research and Education, Madison, WI 53717, USA.
出版信息
Am J Psychiatry. 1995 Sep;152(9):1368-71. doi: 10.1176/ajp.152.9.1368.
OBJECTIVE
The authors examined the efficacy of sertraline in the treatment of social phobia.
METHOD
In a double-blind crossover study, 12 outpatients were randomly assigned to 10 weeks of sertraline (50-200 mg/day, flexible dosing) and 10 weeks of placebo.
RESULTS
A statistically significant improvement in scores on the Liebowitz Social Anxiety Scale was found with sertraline but not with placebo. There was no significant difference between scores obtained with computer- and clinician-administered versions of the Liebowitz Social Anxiety Scale, and the majority of patients preferred to be interviewed by the computer.
CONCLUSIONS
Sertraline seems a safe and effective treatment for social phobia, and computer administration may be a preferable mode of assessment with socially phobic patients.
目的
作者研究了舍曲林治疗社交恐惧症的疗效。
方法
在一项双盲交叉研究中，12名门诊患者被随机分配接受为期10周的舍曲林治疗（50 - 200毫克/天，灵活给药）和为期10周的安慰剂治疗。
结果
使用舍曲林治疗后，利博维茨社交焦虑量表得分有统计学意义的改善，而使用安慰剂则无此效果。利博维茨社交焦虑量表由计算机 administered 和临床医生 administered 版本所获得分之间无显著差异，且大多数患者更喜欢由计算机进行访谈。
结论
舍曲林似乎是治疗社交恐惧症的一种安全有效的方法，并且计算机 administered 可能是评估社交恐惧症患者的一种更可取的方式。
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