Boldt J, Heesen M, Müller M, Hempelmann G
Abteilung Anaesthesiologie und Operative Intensivmedizin, Justus-Liebig-Universität Giessen.
Anaesthesist. 1995 Jun;44(6):423-8. doi: 10.1007/s001010050171.
The introduction of flow-directed pulmonary artery (PA) catheters has helped to improve our knowledge of cardiovascular physiology. There have been several developments of this equipment in recent years, including continuous monitoring of mixed-venous O2 saturation (SvO2) and cardiac output (CO). The high purchase price, however, is an obstacle to its use in the critically ill. The aim of the present study was to analyse the actual costs of these devices in comparison to standardly used intermittent monitoring of SvO2 and CO. METHODS. Thirty critically ill patients in a surgical intensive care unit (ICU) were prospectively studied. PA catheter monitoring was indicated by physicians who were not involved in the study. The patients were randomly allocated to one of the following groups: 1. a standard PA catheter was used, and SvO2 and CO were intermittently measured 6 times a day on a routine basis and additionally when necessary from the clinical point of view; 2. SvO2 was continuously measured using a fiberoptic PA catheter; and 3. CO was continuously monitored using a newly developed PA catheter. Costs for the catheter equipment and laboratory analyses (SvO2) were calculated and the durations of intermittent monitoring techniques were measured. Costs for the 'hardware' (monitor, blood gas analyser) were not taken into account. SvO2 was measured by the ICU staff using an ICU-owned blood gas analyser (4.78 DM/analysis) and by a central laboratory unit, which had to be paid for its analyses (30.50 DM/analysis), respectively. RESULTS. The groups were comparable with regard to their demographic data. A total of 378 intermittent measurements of SvO2 and 449 mean CO measurements (1611 single bolus CO measurements) were carried out in the patients in whom a standard PA catheter was inserted. For daily calibration, a total of 50 single SvO2 measurements were done in the group in which SvO2 was continuously monitored. A total of 27.7 h were spent for intermittent SvO2 measurements (time range of one analysis using the ICU-based blood gas analyser: 4.0 to 7.9 min); intermittent CO monitoring took a total of 14.2 h (time range of one mean CO measurement: 1.6 to 3.0 min). When blood gases were analysed by a central laboratory unit, costs for intermittent SvO2 were tremendously higher than when monitored continuously. CONCLUSION. Monitoring devices that provide us with continuous information on the patient's state may have advantages in the management of the critically ill. Whether the patient's 'outcome' can be improved by monitoring SvO2 and CO continuously was not addressed by the present study. Instead, this study focused on the question of whether these devices are more cost-intensive than standard PA catheter monitoring systems. Costs for laboratory analyses can blunt the advantage of lower costs for the standard PA catheter. Intermittent (standard) monitoring of SvO2 and CO was significantly more time-consuming than the continuous methods. It can be summarised that although purchase costs for the more advanced PA catheters are higher than for standard PA catheters, the use of these continuous monitoring devices in the critically ill can be justified from a financial point of view.
血流导向肺动脉导管的引入有助于增进我们对心血管生理学的认识。近年来,该设备有了多项改进,包括对混合静脉血氧饱和度(SvO2)和心输出量(CO)的持续监测。然而,其高昂的购置价格阻碍了它在重症患者中的使用。本研究的目的是分析这些设备的实际成本,并与标准的间歇性SvO2和CO监测方法进行比较。方法:前瞻性研究了外科重症监护病房(ICU)的30例重症患者。由未参与研究的医生决定是否使用肺动脉导管监测。患者被随机分为以下几组:1. 使用标准肺动脉导管,每天常规间歇性测量SvO2和CO 6次,必要时根据临床情况额外测量;2. 使用光纤肺动脉导管持续测量SvO2;3. 使用新开发的肺动脉导管持续监测CO。计算导管设备和实验室分析(SvO2)的成本,并测量间歇性监测技术的时长。未将“硬件”(监护仪、血气分析仪)的成本计算在内。SvO2由ICU工作人员使用ICU自备的血气分析仪测量(每次分析4.78德国马克),以及由中央实验室测量(每次分析需付费30.50德国马克)。结果:各组的人口统计学数据具有可比性。在插入标准肺动脉导管的患者中,共进行了378次SvO2间歇性测量和449次平均CO测量(1611次单次团注CO测量)。在持续监测SvO2的组中,为进行每日校准共进行了50次单次SvO2测量。间歇性SvO2测量共花费27.7小时(使用ICU血气分析仪进行一次分析的时间范围:4.0至7.9分钟);间歇性CO监测共花费14.2小时(一次平均CO测量的时间范围:1.6至3.0分钟)。当由中央实验室分析血气时,间歇性SvO2的成本比持续监测时高得多。结论:能为我们提供患者状态持续信息的监测设备在重症患者管理中可能具有优势。本研究未探讨持续监测SvO2和CO是否能改善患者的“预后”。相反,本研究关注的问题是这些设备是否比标准肺动脉导管监测系统成本更高。实验室分析成本可能会削弱标准肺动脉导管成本较低的优势。SvO2和CO的间歇性(标准)监测比持续监测方法耗时显著更多。可以总结为,尽管更先进的肺动脉导管的购置成本高于标准肺动脉导管,但从财务角度来看,在重症患者中使用这些持续监测设备是合理的。