Rada R T, Kellner R
J Am Geriatr Soc. 1976 Mar;24(3):105-7. doi: 10.1111/j.1532-5415.1976.tb04280.x.
Thiothixene was used in a four-week double-blind placebo-controlled study of 42 geriatric patients with chronic organic brain syndrome (psychotic or nonpsychotic). The results, according to several rating measures, showed no significant difference between placebo and thiothixene. Side effects were mild and few. These data support the safety of thiothixene therapy for geriatric patients; however, there is no conclusive evidence of its efficacy in the treatment of chronic organic brain syndrome.
在一项针对42名患有慢性器质性脑综合征（精神病性或非精神病性）的老年患者的为期四周的双盲安慰剂对照研究中使用了硫利达嗪。根据多项评分指标，结果显示安慰剂和硫利达嗪之间没有显著差异。副作用轻微且较少。这些数据支持硫利达嗪治疗老年患者的安全性；然而，尚无确凿证据表明其对慢性器质性脑综合征的治疗有效。
