[Effect of ciprofloxacin on luminol-dependent chemiluminescence and adhesion of leukocytes].

The in vitro effect of ciprofloxacin on the luminol-dependent chemiluminescence and adherence of polymorphonuclear leukocytes of guinea pigs was studied with the use of a wide variety of the drug concentrations from 0.1 to 1000 micrograms/ml under two different conditions: during incubation of the cells in the presence of the drug different concentrations and after the cell washing to remove ciprofloxacin. In concentrations of 1 to 100 micrograms/ml ciprofloxacin lowered the chemiluminescence at the average by 20 per cent and in a concentration of 1000 micrograms/ml the drug completely inhibited it. In concentrations of 0.1 to 100 micrograms/ml ciprofloxacin lowered as well the leukocyte adherence.