[Effect of lomefloxacin on luminol-dependent chemiluminescence and adhesion of leukocytes].

The in vitro effect of lomefloxacin within the wide dose ranges from 0.1 to 100 micrograms/ml on luminol-dependent chemiluminescence and adherence of polymorphonuclear leukocytes of guinea pigs was studied under two different conditions: during the cell incubation in the presence of various concentrations of the drug and after the cell washing to remove lomefloxacin. In concentrations of 10 and 100 micrograms/ml the drug inhibited the response under the both conditions while in a concentration of 1 microgram/ml it stimulated the chemiluminescence. In concentrations of 0.1 to 100 micrograms/ml lomefloxacin stimulated the leukocyte adherence. The highest stimulation was observed with the use of the drug in a concentration of 1 microgram/ml.