Krol W, Shani J, Czuba Z, Scheller S
Department of Microbiology, Silesian School of Medicine, Zabrze-Rokitnica, Poland.
Z Naturforsch C J Biosci. 1992 Nov-Dec;47(11-12):889-92. doi: 10.1515/znc-1992-11-1216.
The effect of 14 flavones on luminol-dependent chemiluminescence of neutrophils was studied in vitro. Chemiluminescence was used in this study as an indicator for the production of a reactive oxygen species by neutrophils, stimulated by phorbol myristate acetate. While flavone-8-acetic acid, and most of the compounds tested, inhibited chemiluminescence, flavone and its 5-hydroxy-7-methoxy derivatives enhanced it by up to 150%. The most active inhibitors of photon emission were the glycosides. These results indicate that lipophilicity and some structural determinants modulate the chemiluminescent capacity of neutrophils.
体外研究了14种黄酮对嗜中性粒细胞鲁米诺依赖性化学发光的影响。本研究中，化学发光用作嗜中性粒细胞产生活性氧的指标，嗜中性粒细胞由佛波酯乙酸盐刺激产生活性氧。虽然黄酮 - 8 - 乙酸以及大多数测试化合物抑制化学发光，但黄酮及其5 - 羟基 - 7 - 甲氧基衍生物可将其增强高达150%。最有效的光子发射抑制剂是糖苷。这些结果表明，亲脂性和一些结构决定因素调节嗜中性粒细胞的化学发光能力。
