内毒素诱导的水貂淀粉样变性中与淀粉样蛋白相关的血清蛋白SAA
Amyloid-related serum protein SAA in endotoxin-induced amyloidosis of the mink.
作者信息
Anders R F, Nordstoga K, Natvig J B, Husby G
出版信息
J Exp Med. 1976 Mar 1;143(3):678-83. doi: 10.1084/jem.143.3.678.
Abstract
The concentration of the amyloid AA-related serum protein (SAA) was markedly increased after endotoxin injections in mink, mouse, rabbit, and man. It was particularly studied during the development of endotoxin-induced amyloidosis of the mink. Protein SAA was markedly elevated in all mink 24 h after the first endotoxin injection but had fallen to relatively low levels before the onset of amyloidosis at about 4 wk. These results are consistent with SAA being a circulating precursor of the amyloid fibril protein, AA. However, both proteins may be derived by proteolysis from a common precursor.
摘要
在内毒素注射后，水貂、小鼠、兔子和人类体内的淀粉样蛋白AA相关血清蛋白（SAA）浓度显著升高。尤其在水貂内毒素诱导的淀粉样变性发展过程中对其进行了研究。首次注射内毒素24小时后，所有水貂体内的蛋白SAA均显著升高，但在约4周淀粉样变性发病前已降至相对较低水平。这些结果与SAA作为淀粉样原纤维蛋白AA的循环前体一致。然而，这两种蛋白可能都是由一种共同前体通过蛋白水解产生的。
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