Haines C J, Chung T K, Leung P C, Hsu S Y, Leung D H
Department of Obstetrics and Gynaecology, Chinese University of Hong Kong, New Territories.
Bone. 1995 May;16(5):529-31. doi: 10.1016/8756-3282(95)00084-q.
Both estrogen and calcium have been shown to be of benefit in reducing the incidence of osteoporosis in postmenopausal women. It has been suggested that estrogen promotes the intestinal absorption of calcium, and this effect may especially benefit postmenopausal women with a low dietary intake of calcium. The purpose of this study was to examine the effect of calcium supplementation on the bone mineral density (BMD) of postmenopausal women using estrogen replacement therapy. BMD measurements were made over 12 months in two groups of postmenopausal women, one having treatment with estrogen alone, and the second having estrogen and 1000 mg of supplemental calcium each day. There was no significant reduction in BMD between the two groups over the 12-month study period. Those in the group having supplemental calcium had a significant increase in BMD at the femoral neck (p = 0.023), but not in other areas of the femur nor in the lumbar spine. The results of this study suggest that the addition of supplemental calcium may improve the bone mass of postmenopausal women using estrogen who have a low dietary calcium intake. This benefit appears to be more pronounced in corticocancellous than in trabecular bone, and may therefore have a greater effect on the femoral neck than the lumbar spine.
雌激素和钙都已被证明有助于降低绝经后女性骨质疏松症的发病率。有人认为，雌激素可促进肠道对钙的吸收，这种作用可能对钙摄入量低的绝经后女性尤其有益。本研究的目的是研究补充钙对接受雌激素替代疗法的绝经后女性骨密度（BMD）的影响。对两组绝经后女性进行了为期12个月的骨密度测量，一组仅接受雌激素治疗，另一组每天接受雌激素和1000毫克补充钙治疗。在12个月的研究期内，两组之间的骨密度没有显著降低。补充钙的组在股骨颈处的骨密度显著增加（p = 0.023），但在股骨的其他部位和腰椎处没有增加。本研究结果表明，补充钙可能会改善钙摄入量低且正在使用雌激素的绝经后女性的骨量。这种益处似乎在皮质骨松质中比在小梁骨中更明显，因此对股骨颈的影响可能比对腰椎的影响更大。
