Department of Nuclear Medicine, Huashan Hospital, Fudan University, 12 Wulumuqi Zhong Rd, Shanghai 200040, People's Republic of China.
Osteoporos Int. 2012 May;23(5):1563-70. doi: 10.1007/s00198-012-1895-z. Epub 2012 Jan 27.
Eighteen months of daily consumption of milk containing 250 mg calcium prevented bone mineral density (BMD) loss at the hip and the femoral neck in postmenopausal Chinese women aged 45 to 65.
Estrogen-related bone loss in postmenopausal women can be prevented by the consumption of milk with high doses of calcium and soymilk with high doses of isoflavones. However, high doses of calcium and isoflavones may not be necessary to attain a beneficial effect of milk and soymilk on BMD. We hypothesized that BMD will increase in postmenopausal Chinese women who consume daily 250 mg calcium in milk or soymilk. Milk prevented bone loss at the hip and the femoral neck in postmenopausal Chinese women.
A total of 141 eligible Chinese women without osteoporosis, aged 45-65, and postmenopausal for more than 2 years were randomized into groups receiving for 18 months (A) milk with 250 mg calcium daily, (B) soymilk with 250 mg calcium daily, or (C) neither milk nor soymilk. Dual-energy X-ray absorptiometry measured the BMD of the spine and hip at 0, 6, 12, and 18 months.
The BMD in the hip (2.52%) and the femoral neck (2.82%) of the women consuming milk was significantly higher (hip, P = 0.01; femoral neck, P < 0.0000001). The women in the control group experienced a reduction in BMD at all sites; the reduction in BMD was only significant at the hip during 12 months (P = 0.008) and at the femoral neck during 18 months (P = 0.005).
Daily consumption of milk containing 250 mg calcium over 18 months prevents BMD loss at the hip and the femoral neck in postmenopausal Chinese women.
研究每日摄入 250mg 钙的牛奶对 45-65 岁绝经后中国女性髋部和股骨颈骨密度（BMD）的影响。
共纳入 141 名符合条件的、无骨质疏松症的中国女性，年龄 45-65 岁，绝经时间超过 2 年，随机分为 3 组，分别接受 18 个月的干预：（A）每天摄入 250mg 钙的牛奶；（B）每天摄入 250mg 钙的豆浆；（C）不摄入牛奶或豆浆。双能 X 线吸收法测量基线、6、12 和 18 个月时的脊柱和髋部 BMD。
与对照组相比，摄入牛奶的女性髋部（2.52%）和股骨颈（2.82%）的 BMD 显著增加（髋部，P=0.01；股骨颈，P<0.0000001）。对照组所有部位的 BMD 均呈下降趋势，仅在 12 个月时髋部（P=0.008）和 18 个月时股骨颈（P=0.005）的下降具有统计学意义。
18 个月内每日摄入 250mg 钙的牛奶可预防绝经后中国女性髋部和股骨颈 BMD 丢失。
