Kossovsky N, Freiman C J
Department of Pathology and Laboratory Medicine, University of California, Los Angeles School of Medicine 90024-1732, USA.
J Biomater Sci Polym Ed. 1995;7(2):101-13. doi: 10.1163/156856295x00625.
Silicones, model biomaterials with almost ubiquitous applications, are the focus of a contentious debate. In this review, we will consider both established physicochemical phenomena and immunological phenomena; and then consider the human clinical phenomena that relate directly to them. We will explore the two competing theories of the biological activity of silicones, and we will discuss the weaknesses in the various arguments that silicone is inert. We conclude that from a pathophysiological perspective, silicones should be expected to be bioactive materials and that the physicochemical and immunological data at the experimental level are compelling.
硅酮是几乎无处不在的应用的典型生物材料，是一场有争议辩论的焦点。在本综述中，我们将考虑既定的物理化学现象和免疫现象；然后考虑与之直接相关的人类临床现象。我们将探讨关于硅酮生物活性的两种相互竞争的理论，并讨论硅酮是惰性的各种论点中的弱点。我们得出结论，从病理生理学角度来看，硅酮应该被视为生物活性材料，并且实验层面的物理化学和免疫学数据令人信服。
