Kossovsky N, Stassi J
Department of Pathology and Laboratory Medicine, University of California, Los Angeles School of Medicine 90024-1732.
Semin Arthritis Rheum. 1994 Aug;24(1 Suppl 1):18-21. doi: 10.1016/0049-0172(94)90105-8.
Historically, silicones have been considered biologically inert materials, and have therefore been used widely in a variety of medical applications. Recently, controversy has arisen concerning the bioreactivity of silicone; reports of adverse inflammatory and immunological complications that may be evoked by silicone breast implants have appeared in the medical literature and have received great attention from the lay press. The phenomena said to be associated with silicones may be attributed pathophysiologically to the inherent surface activity of silicone. The human body's initial response to the silicone of breast implants is the adsorption of various plasma proteins, including clotting and complement proteins, to the implant surface. Other macromolecules in the biological milieu may follow. The conformational integrity of this adsorbed macromolecular layer affects much of the subsequent biological reaction. Clinically silent inflammation, locally significant inflammation, inflammation with constitutional symptoms, and inflammation with immunological activation are possible consequences.
从历史上看，硅酮一直被认为是生物惰性材料，因此被广泛应用于各种医学领域。最近，关于硅酮的生物反应性出现了争议；医学文献中出现了关于硅胶乳房植入物可能引发不良炎症和免疫并发症的报道，并受到了大众媒体的高度关注。据说与硅酮相关的现象在病理生理上可能归因于硅酮固有的表面活性。人体对乳房植入物硅酮的初始反应是各种血浆蛋白，包括凝血蛋白和补体蛋白，吸附到植入物表面。生物环境中的其他大分子可能随后吸附。这种吸附的大分子层的构象完整性影响了许多后续的生物反应。临床上无症状的炎症、局部显著的炎症、伴有全身症状的炎症以及伴有免疫激活的炎症都是可能的后果。
