Wocial B, Ignatowska-Switalska H, Pruszczyk P, Jedrusik P, Januszewicz A, Lapinski M, Januszewicz W, Zukowska-Grojec Z
Department of Hypertension and Angiology, Medical Academy in Warsaw, Poland.
Blood Press. 1995 May;4(3):143-7. doi: 10.3109/08037059509077586.
Neuropeptide-Y (NPY) is a peptide proposed to modulate the effect of the sympathetic nervous system on blood pressure control and contribute to the development of essential hypertension. To assess the possible influence of gender on its role, we evaluated plasma NPY, noradrenaline (NA) and adrenaline (A) concentrations in men and women with essential hypertension. No difference in NPY concentration was found between genders, but NPY concentration was elevated in both hypertensive men and women. NA levels were similar in all investigated hyper- and normotensives, while A was increased only in hypertensive men. These results suggest various patterns of sympatho-adrenal activity in gender subgroups of patients with essential hypertension.
神经肽Y（NPY）是一种被认为可调节交感神经系统对血压控制的作用并促进原发性高血压发展的肽。为评估性别对其作用的可能影响，我们对原发性高血压男性和女性的血浆NPY、去甲肾上腺素（NA）和肾上腺素（A）浓度进行了评估。男女之间未发现NPY浓度存在差异，但高血压男性和女性的NPY浓度均升高。在所有研究的高血压和正常血压者中，NA水平相似，而仅高血压男性的A升高。这些结果提示原发性高血压患者性别亚组中存在不同模式的交感-肾上腺活动。
