Nishida T, Kondo N, Agata H, Fukutomi O, Shinoda S, Shinbara M, Orii T
Department of Pediatrics, Gifu University School of Medicine, Japan.
J Investig Allergol Clin Immunol. 1995 Mar-Apr;5(2):86-90.
The proliferative responses of peripheral blood mononuclear cells (PBMCs) to cow's milk proteins and a casein hydrolysate formula were investigated in 10 cow's milk-sensitive patients. The casein hydrolysate formula reduced the symptoms in seven children but not in three. The proliferative responses of PBMCs to cow's milk proteins and the formula were higher in the three patients whose symptoms were not reduced by casein hydrolysate formula. However, the proliferative responses of PBMCs to hydrolysate formula were lower than those to cow's milk proteins in patients whose symptoms were reduced by casein hydrolysate formula. These results suggest that an elimination diet with casein hydrolysate formula may not be as effective in some patients with cow's milk allergy whose PBMCs proliferate to casein hydrolysate formula.
在10名牛奶敏感患者中研究了外周血单核细胞（PBMC）对牛奶蛋白和酪蛋白水解物配方奶粉的增殖反应。酪蛋白水解物配方奶粉减轻了7名儿童的症状，但另外3名儿童的症状未减轻。在3名症状未因酪蛋白水解物配方奶粉而减轻的患者中，PBMC对牛奶蛋白和该配方奶粉的增殖反应较高。然而，在症状因酪蛋白水解物配方奶粉而减轻的患者中，PBMC对水解物配方奶粉的增殖反应低于对牛奶蛋白的增殖反应。这些结果表明，对于一些PBMC对酪蛋白水解物配方奶粉有增殖反应的牛奶过敏患者，采用酪蛋白水解物配方奶粉的排除饮食可能效果不佳。
