Montone K T, Furth E E, Pietra G G, Gupta P K
Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia 19104, USA.
Diagn Cytopathol. 1995 Jun;12(4):341-4. doi: 10.1002/dc.2840120411.
Adenovirus infection is a rare, but serious infection, during the neonatal period. The actual model of infection at birth is currently unknown, however, several mechanisms have been proposed. We describe a case of fatal neonatal adenovirus pneumonia in a 25-wk gestational age infant. Adenovirus was confirmed by electron microscopy and by in situ hybridization. The maternal cervical/endocervical smear taken prior to the delivery contained epithelial cells with changes suggestive of adenovirus, which was confirmed by in situ hybridization on the smear. These findings suggest that ascending viral infection is a factor in the pathogenesis of neonatal adenovirus infection. The identification and reporting of adenovirus may be important during pregnancy in order to avoid delay in delivery of the fetus once membranes have ruptured.
腺病毒感染在新生儿期是一种罕见但严重的感染。目前尚不清楚出生时的实际感染模式，不过，已经提出了几种机制。我们描述了一例孕25周胎龄婴儿发生的致命性新生儿腺病毒肺炎病例。通过电子显微镜和原位杂交确诊为腺病毒感染。分娩前采集的产妇宫颈/宫颈内膜涂片含有提示腺病毒感染的上皮细胞变化，涂片原位杂交证实了这一点。这些发现表明上行性病毒感染是新生儿腺病毒感染发病机制中的一个因素。孕期识别和报告腺病毒感染可能很重要，以便在胎膜破裂后避免延迟胎儿分娩。
