Herrera Acosta J
Departamento de Nefrología, Instituto Nacional de Cardiología Ignacio Chávez.
Gac Med Mex. 1994 May-Jun;130(3):126-7.
It was recently suggested that insulin resistance present in diabetes and obesity may contribute to hypertension that frequently associates with both conditions. It has been proposed that the resulting hyperinsulinemia may induce hypertension through four possible mechanisms: Its trophic effect on vascular smooth muscle cells, increasing cytosolic calcium, increasing tubular sodium reabsorption or by stimulating adrenergic activity. Other studies however, did not confirm the ability of insulin to elevate blood pressure suggesting that the association between hypertension and hyperinsulinemia may no be a cause effect relationship, instead both phenomena may be secondary to the same cause. It has been suggested that adrenergic hyperactivity, changes in cellular ionic flux and alterations in microcirculation can induce both hypertension and insulin resistance.
最近有观点认为，糖尿病和肥胖症中存在的胰岛素抵抗可能导致高血压，而高血压常与这两种病症相关联。有人提出，由此产生的高胰岛素血症可能通过四种可能的机制诱发高血压：对血管平滑肌细胞的营养作用、增加细胞内钙、增加肾小管钠重吸收或通过刺激肾上腺素能活性。然而，其他研究并未证实胰岛素具有升高血压的能力，这表明高血压与高胰岛素血症之间的关联可能不是因果关系，相反，这两种现象可能继发于同一原因。有人提出，肾上腺素能活动亢进、细胞离子通量变化和微循环改变可同时诱发高血压和胰岛素抵抗。
