Meehan W P, Darwin C H, Maalouf N B, Buchanan T A, Saad M F
Department of Medicine, University of Southern California Medical School, Los Angeles 90038.
Przegl Lek. 1994;51(3):135-48.
It has been postulated that insulin resistance and the concomitant compensatory hyperinsulinemia contribute to the pathogenesis of hypertension; possible by stimulating the sympathetic nervous system, promoting renal sodium reabsorption, modulating cation transport, and/or stimulating vascular smooth muscle hypertrophy. The purpose of this article is to present a comprehensive up-to-date review of the literature and critically examine the insulin resistance-hyperinsulinemia-hypertension hypothesis.
据推测，胰岛素抵抗及随之而来的代偿性高胰岛素血症会导致高血压的发病；可能是通过刺激交感神经系统、促进肾脏对钠的重吸收、调节阳离子转运和/或刺激血管平滑肌肥大来实现的。本文的目的是对文献进行全面的最新综述，并批判性地审视胰岛素抵抗-高胰岛素血症-高血压假说。
