Rebolledo A, Milesi V, Rinaldi G, Grassi A
Departamento de Ciencias Biológicas, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, Argentina.
Medicina (B Aires). 1996;56(5 Pt 1):518-26.
Several epidemiological studies have shown that there is a relationship between hyperinsulinemia, insulin resistance and arterial hypertension. Insulin produces sympathetic nervous system stimulation, enhances renal sodium retention and it directly modifies vascular mechanisms involved in both contraction and relaxation of the vascular smooth muscle. These actions of insulin could lead either to elevation or reduction of blood pressure. The absence of vasodilation due to insulin resistance and/or the enhancement of the hypertensive effects due to hyperinsulinemia could be the link between insulin and hypertension.
多项流行病学研究表明，高胰岛素血症、胰岛素抵抗与动脉高血压之间存在关联。胰岛素可刺激交感神经系统，增强肾脏对钠的潴留，并且直接改变参与血管平滑肌收缩和舒张的血管机制。胰岛素的这些作用可能导致血压升高或降低。由于胰岛素抵抗导致的血管舒张功能缺失和/或高胰岛素血症导致的高血压效应增强，可能是胰岛素与高血压之间的联系。
