Caplehorn J R, Ross M W
Department of Public Health, University of Sydney, N.S.W., Australia.
Int J Addict. 1995 May;30(6):685-98. doi: 10.3109/10826089509048753.
Survey data were used to study the association of methadone maintenance and needle-sharing. An ordinal scale of HIV risk was derived from the number of persons from whom subjects reported accepting a used needle and syringe in the 6 months prior to interview. The odds of respondents in methadone maintenance being in the higher risk group were half those of daily heroin users not in treatment for all three transitions in a four-level ordinal scale of risk (OR 0.55, 95% CL 0.33 to 0.90, ordinal logistic regression). This association disappeared when methadone patients who had not injected in the month prior to interview were excluded from the analysis. Subjects' knowledge concerning HIV and AIDS had no measurable association with the outcome. It is concluded that methadone maintenance reduces heroin addicts' risk of infection with HIV by reducing the likelihood of their injecting drugs rather than by changing their injecting behavior.
调查数据被用于研究美沙酮维持治疗与共用针头之间的关联。根据受访者在访谈前6个月内报告接受他人用过的针头和注射器的人数得出了一个HIV风险的序数量表。在一个四级风险序数量表的所有三个转变中,接受美沙酮维持治疗的受访者处于高风险组的几率是未接受治疗的每日海洛因使用者的一半(比值比0.55,95%可信区间0.33至0.90,序贯逻辑回归)。当将访谈前一个月内未注射过的美沙酮患者排除在分析之外时,这种关联消失了。受试者关于HIV和艾滋病的知识与结果没有可测量的关联。得出的结论是,美沙酮维持治疗通过降低海洛因成瘾者注射毒品的可能性而非改变他们的注射行为来降低其感染HIV的风险。