Kono K, Arakawa K
Second Department of Internal Medicine, School of Medicine, Fukuoka University, Japan.
J Hosp Infect. 1995 Apr;29(4):265-73. doi: 10.1016/0195-6701(95)90273-2.
Bacteriological and clinical studies were carried out on 280 strains of Staphylococcus aureus isolated in clinics and hospitals in the Fukuoka city area from September 1990 to March 1991. The percentage of methicillin-resistant S. aureus (MRSA) strains studied was 41.4% (116 of 280). Of 116 MRSA strains, 48 (41.3%) produced coagulase VII and 21 (18.1%) produced coagulase II. The mean age of the patients who harboured MRSA, 70.5 +/- 16.9 years, was significantly higher than that of patients with methicillin-sensitive S. aureus (MSSA), 44.2 +/- 29.3 years (P < 0.001). MRSA was detected more frequently than MSSA in sputum (P < 0.01), while MSSA was detected more frequently than MRSA in pus (P < 0.01). Ninety (89.1%) of 101 strains of MRSA were isolated from inpatients and 98 (71.0%) of 130 strains of MSSA were isolated from outpatients. Similar number of MRSA strains were recovered in a variety of hospitals, indicating that there was no relationship between hospital size (number of beds) and the incidence of MRSA. As for drug susceptibility, coagulase VII-producing MRSA strains were more sensitive to clidamycin (P < 0.01) and more resistant to minocycline (P < 0.01) than were other MRSA strains.
1990年9月至1991年3月期间，对福冈市地区诊所和医院分离出的280株金黄色葡萄球菌进行了细菌学和临床研究。所研究的耐甲氧西林金黄色葡萄球菌（MRSA）菌株百分比为41.4%（280株中的116株）。在116株MRSA菌株中，48株（41.3%）产生凝固酶VII，21株（18.1%）产生凝固酶II。携带MRSA的患者平均年龄为70.5±16.9岁，显著高于耐甲氧西林金黄色葡萄球菌敏感株（MSSA）患者的平均年龄44.2±29.3岁（P<0.001）。在痰液中检测到MRSA的频率高于MSSA（P<0.01），而在脓液中检测到MSSA的频率高于MRSA（P<0.01）。101株MRSA菌株中的90株（89.1%）从住院患者中分离得到，130株MSSA菌株中的98株（71.0%）从门诊患者中分离得到。在各种医院中回收的MRSA菌株数量相似，表明医院规模（床位数）与MRSA发病率之间没有关系。至于药敏情况，产生凝固酶VII的MRSA菌株比其他MRSA菌株对克林霉素更敏感（P<0.01），对米诺环素更耐药（P<0.01）。
