Bishun N, Mills J, Parke J V, Williams D C
Mutat Res. 1975 Dec;33(2-3):299-310. doi: 10.1016/0027-5107(75)90205-5.
A study has been made of the chromosome numbers and characteristics of leucocytes cultured from mothers (a total of 77) who had taken one or more types of oral contraceptive, and their babies (108), and compared with similar numbers of control subjects. When the total cytogenetic results from test and control mothers were compared, no significant differences in frequency or type of chromosome abnormalities was observed. However, with certain types of oral contraceptive, minor differences in the numbers of chromosome abnormalities were found between test and control groups and the significance of these findings are discussed. The only significant abnormalities observed in the babies from mothers taking oral contraceptives were slight increases in the numbers who had cells with less than 46 chromosomes and who exhibited chromosomal gaps. The number of abnormal cells was significantly higher in babies born to mothers who had been taking norethynodrel (Conovid) (4.6% abnormal cells in test babies; 2.0% in controls).
对服用过一种或多种口服避孕药的母亲（共77名）及其婴儿（108名）培养的白细胞的染色体数目和特征进行了研究，并与相同数量的对照对象进行了比较。当比较试验组和对照组母亲的细胞遗传学总体结果时，未观察到染色体异常频率或类型的显著差异。然而，对于某些类型的口服避孕药，试验组和对照组之间在染色体异常数量上存在微小差异，并对这些发现的意义进行了讨论。在服用口服避孕药的母亲所生的婴儿中观察到的唯一显著异常是染色体数目少于46条的细胞数量以及出现染色体间隙的细胞数量略有增加。服用炔诺酮（复方炔诺酮片）的母亲所生婴儿的异常细胞数量显著更高（试验组婴儿中4.6%为异常细胞；对照组中为2.0%）。
