核形态测量学在肾嗜酸细胞瘤与肾细胞癌鉴别诊断中的应用
Nuclear morphometry in differential diagnosis of renal oncocytoma and renal cell carcinoma.
作者信息
Castrén J P, Kuopio T, Nurmi M J, Collan Y U
机构信息
Department of Pathology, University of Turku, Finland.
出版信息
J Urol. 1995 Oct;154(4):1302-6.
PURPOSE
Morphometric distinction of renal oncocytoma and renal cell carcinoma was attempted.
MATERIALS AND METHODS
Nuclear morphometric measurements were done from sections of 16 histologically diagnosed renal oncocytomas and renal cell carcinoma controls (grade 1 or 2, stage T1 to 2N0M0).
RESULTS
Oncocytomas could be distinguished from carcinomas on the basis of nuclear morphometry in more than 80% of the cases. Especially, the shape descriptors (form factors) were significantly different between oncocytomas and carcinomas.
CONCLUSIONS
Morphometrically determined nuclear shape descriptors can be used to support diagnostic decisions in problematic cases.
目的
尝试对肾嗜酸细胞瘤和肾细胞癌进行形态计量学区分。
材料与方法
对16例经组织学诊断的肾嗜酸细胞瘤和肾细胞癌对照（1或2级，T1至2N0M0期）切片进行细胞核形态计量测量。
结果
在超过80%的病例中，嗜酸细胞瘤可根据细胞核形态计量学与癌进行区分。特别是，嗜酸细胞瘤和癌之间的形状描述符（形态因子）有显著差异。
结论
形态计量学确定的细胞核形状描述符可用于辅助疑难病例的诊断决策。
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