良性肝病中的甲胎蛋白（AFP）。正常肝脏再生不会诱导AFP合成的证据。
Alpha-fetoprotein (AFP) in benign liver disease. Evidence that normal liver regeneration does not induce AFP synthesis.
作者信息
Alpert E, Feller E R
出版信息
Gastroenterology. 1978 May;74(5 Pt 1):856-8.
PMID:76587
Abstract
One hundred sera samples, obtained during the early postoperative period from 11 patients after a partial hepatectomy, were assayed for alpha-fetoprotein (AFP). None were AFP-positive by radioimmunoassay, despite clinical and biochemical recovery associated with normal liver regeneration. AFP was elevated in 29% of patients with acute hepatitis, 34% of patients with chronic active hepatitis, and in 75% of patients with massive hepatic necrosis. The mechanism and significance of AFP elevations in some patients with acute and chronic hepatitis is uncertain but probably does not reflect normal liver regeneration.
摘要
从11例接受部分肝切除术后的患者术后早期获取了100份血清样本，检测其中的甲胎蛋白（AFP）。尽管临床和生化指标恢复且肝脏正常再生，但通过放射免疫测定法，无一例样本AFP呈阳性。急性肝炎患者中有29%的AFP升高，慢性活动性肝炎患者中有34%的AFP升高，而在大块肝坏死患者中有75%的AFP升高。急性和慢性肝炎部分患者AFP升高的机制及意义尚不确定，但可能并不反映正常肝脏再生。
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