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微小病变性肾小球病中蛋白尿与上皮细胞变化的关系。

Relationship between proteinuria and epithelial cell changes in minimal lesion glomerulopathy.

作者信息

Powell H R

出版信息

Nephron. 1976;16(4):310-7. doi: 10.1159/000180616.

DOI:10.1159/000180616
PMID:765875
Abstract

The degree of fusion of glomerular epithelial cell foot processes was quantitated by determining the mean number of inter-process slip pores along 10 mum of basement membrane of peripheral capillary walls in 45 children with steroid-responsive nephrotic syndrome and minimal lesion glomerulopathy. Fusion was present in all biopsies performed when the child had proteinuria, but after remission the number of slit pores increased progressively towards normal over the next 4 weeks. There was a close correlation between the degree of fusion and the amount of proteinuria in those biopsied before remission.

摘要

通过测定45例激素反应性肾病综合征和微小病变性肾小球病患儿外周毛细血管壁基底膜10μm长度上的平均细胞间滑动孔数量,对肾小球上皮细胞足突融合程度进行定量分析。当患儿出现蛋白尿时,所有活检标本均存在融合现象,但缓解后,在接下来的4周内,裂孔数量逐渐增加至接近正常。在缓解前进行活检的患儿中,融合程度与蛋白尿量密切相关。

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