Valladares-Neto D C, Buchsbaum M S, Evans W J, Nguyen D, Nguyen P, Siegel B V, Stanley J, Starr A, Guich S, Rice D
Fundação Hospitalar do Estado de Minas Gerais, Brazil.
Neuropsychobiology. 1995;31(4):173-81. doi: 10.1159/000119189.
Quantitative scalp EEG from 32 channels and the cerebral glucose metabolic rate from the 32 underlying cortical positions as assessed by positron emission tomography (PET) with 18F-2-deoxyglucose (FDG) were obtained on 36 patients with mild to moderate senile dementia of the Alzheimer type and 17 age- and sex-matched normal control subjects. Subjects performed a verbal memory task during uptake of FDG. There were significant correlations between both delta amplitude and metabolic rate and memory performance during FDG uptake. Patients with Alzheimer's disease had significantly greater left temporal delta amplitude and lower glucose metabolic rates. Both EEG delta in microvolts and metabolic rate had similar diagnostic sensitivity, but PET had fewer false positives among normals. The left amygdala had the highest sensitivity and percent correct diagnosis of any brain area. Temporal lobe EEG delta activity showed higher correlations with hippocampal metabolic rate than metabolic rate directly under the electrode.
对36例轻度至中度阿尔茨海默型老年痴呆患者及17名年龄和性别匹配的正常对照者，获取了32导的定量头皮脑电图以及通过18F - 脱氧葡萄糖（FDG）正电子发射断层扫描（PET）评估的32个相应皮质下位置的脑葡萄糖代谢率。在FDG摄取期间，受试者进行了言语记忆任务。在FDG摄取期间，δ波振幅和代谢率与记忆表现之间均存在显著相关性。阿尔茨海默病患者的左侧颞叶δ波振幅显著更高，葡萄糖代谢率更低。脑电图以微伏计的δ波和代谢率具有相似的诊断敏感性，但PET在正常人群中的假阳性较少。左侧杏仁核在所有脑区中具有最高的敏感性和正确诊断率。颞叶脑电图δ波活动与海马代谢率的相关性高于电极正下方的代谢率。
