Miller J D, de Leon M J, Ferris S H, Kluger A, George A E, Reisberg B, Sachs H J, Wolf A P
J Cereb Blood Flow Metab. 1987 Apr;7(2):248-51. doi: 10.1038/jcbfm.1987.50.
Elderly controls and probable Alzheimer's disease patients underwent serial positron emission tomography (PET) studies during a baseline condition and while performing a verbal memory task. For the temporal lobes, all 7 Alzheimer patients demonstrated a relative shift in glucose metabolic rates to the right hemisphere during the memory condition relative to baseline, and 5 of 7 controls showed a shift to the left hemisphere. Baseline absolute regional metabolic rates replicate previous findings and were somewhat less useful than the memory challenge in differentiating patients from controls. These results indicate that a temporal lobe abnormality in Alzheimer's disease is related to memory performance.
老年对照者和疑似阿尔茨海默病患者在基线状态以及执行言语记忆任务时接受了系列正电子发射断层扫描（PET）研究。对于颞叶，所有7名阿尔茨海默病患者在记忆状态下相对于基线时，葡萄糖代谢率相对向右半球转移，7名对照者中有5名向左半球转移。基线绝对区域代谢率重复了先前的研究结果，在区分患者与对照者方面，其作用不如记忆挑战明显。这些结果表明，阿尔茨海默病中的颞叶异常与记忆表现有关。
