苯妥英对患有高钾性周期性麻痹的夸特马骨骼肌的影响。

Effect of phenytoin on skeletal muscle from quarter horses with hyperkalaemic periodic paralysis.

作者信息

Beech J, Fletcher J E, Tripolitis L, Lindborg S, Dawso T

机构信息

Department of Clinical Studies, University of Pennsylvania, School of Veterinary Medicine, New Bolton Center, Kennett Square 19348, USA.

出版信息

Res Vet Sci. 1995 May;58(3):206-11. doi: 10.1016/0034-5288(95)90103-5.

DOI:10.1016/0034-5288(95)90103-5

PMID:7659842

Abstract

The contractile activity, the threshold for calcium-induced calcium release in fractions of sarcoplasmic reticulum and the potassium concentration were determined in preparations of semimembranosus muscle from normal quarter horses and quarter horses with hyperkalaemic periodic paralysis before and after they were treated with phenytoin. Before the treatment there was no difference in caffeine contracture or electrically elicited twitch response between the two groups. For one week after the treatment, the time to peak tension of caffeine contractures was significantly (P < 0.005) reduced in the horses with hyperkalaemic periodic paralysis but unchanged in the normal horses. The variance but not the mean values for the threshold for Ca(2+)-induced Ca2+ release from the sarcoplasmic reticulum was greater for the horses with hyperkalaemic period paralysis before but not after the treatment with phenytoin.

摘要

在苯妥英治疗前后，分别测定了正常四分之一马和患有高钾性周期性麻痹的四分之一马的半膜肌制剂的收缩活性、肌浆网各部分钙诱导钙释放的阈值以及钾浓度。治疗前，两组之间的咖啡因挛缩或电诱发抽搐反应没有差异。治疗后一周，患有高钾性周期性麻痹的马的咖啡因挛缩达到峰值张力的时间显著缩短（P < 0.005），而正常马则无变化。在使用苯妥英治疗前，患有高钾性周期性麻痹的马从肌浆网释放Ca(2+)诱导Ca2+释放的阈值的方差较大，但均值不变，治疗后则不存在这种情况。