苯妥英对两匹患有高钾性周期性麻痹的肌强直马的影响。

Effects of phenytoin in two myotonic horses with hyperkalemic periodic paralysis.

作者信息

Beech J, Fletcher J E, Tripolitis L, Lindborgh S

机构信息

Department of Clinical Studies, University of Pennsylvania, School of Veterinary Medicine, Kennett Square 19348.

出版信息

Muscle Nerve. 1992 Aug;15(8):932-6. doi: 10.1002/mus.880150811.

DOI:10.1002/mus.880150811

PMID:1495509

Abstract

The effects of phenytoin treatment were evaluated in 2 myotonic horses with hyperkalemic periodic paralysis (HPP). Phenytoin treatment abolished the clinical signs of muscle fasciculations following oral potassium challenge and decreased or abolished repetitive firing and myotonic discharges found on electromyographic examination. In both horses, an abnormally low threshold for calcium-induced calcium release was measured in heavy sarcoplasmic reticulum fractions from skeletal muscle, and this threshold increased with phenytoin treatment. Results suggest phenytoin is useful in modifying disordered ion regulation in the sarcolemma and sarcoplasmic reticulum of skeletal muscle in equine hyperkalemic periodic paralysis.

摘要

对2匹患有高钾性周期性麻痹（HPP）的肌强直马进行了苯妥英治疗效果评估。苯妥英治疗消除了口服钾激发后肌肉束颤的临床体征，并减少或消除了肌电图检查中发现的重复放电和肌强直放电。在这两匹马中，测量到骨骼肌重肌浆网部分钙诱导钙释放的阈值异常低，且该阈值随苯妥英治疗而升高。结果表明，苯妥英在改善马高钾性周期性麻痹骨骼肌肌膜和肌浆网中紊乱的离子调节方面是有用的。