Contreras G, Glasinovic J C, González C, Duarte I, Mege R M, Villarroel L
Hospital Sótero del Rio, Departamento de Gastroenterología, Universidad Católica de Chile, Santiago de Chile.
Rev Med Chil. 1994 Oct;122(10):1158-62.
We studied 793 patients subjected to cholecystectomy to determine a) the relative frequency of cholesterolosis and cholelithiasis, b) the effects of their association on the natural history of biliary disease, c) the characteristics of gallstones associated to cholesterolosis and d) factors potentially associated to their pathogenesis. The gallbladders of all patients were examined and in 289 subjects a preoperative clinical history was taken. We observed that cholesterolosis is associated to earlier clinical manifestations of biliary disease and cholecystectomy, to a greater frequency of single calculus and to a higher weight/height index. It is concluded that there are relationships between the pathogenesis of cholesterolosis and cholelithiasis and that their association favors the development of clinical manifestations.
我们对793例行胆囊切除术的患者进行了研究，以确定：a）胆固醇沉着症和胆石症的相对发生率；b）它们的关联对胆道疾病自然病程的影响；c）与胆固醇沉着症相关的胆结石特征；d）与其发病机制潜在相关的因素。对所有患者的胆囊进行了检查，并对289名受试者进行了术前临床病史采集。我们观察到，胆固醇沉着症与胆道疾病及胆囊切除术的更早临床表现、更高的单发性结石发生率以及更高的体重/身高指数相关。得出的结论是，胆固醇沉着症和胆石症的发病机制之间存在关联，且它们的关联有利于临床表现的发展。
