Schneider M C, Santos-Burgoa C
Centro Nacional de Epidemiologia, Fundacão Nacional de Saúde, Ministério da Saúde, Brasil.
Rev Saude Publica. 1994 Dec;28(6):454-63. doi: 10.1590/s0034-89101994000600010.
A historical review of the treatment of human rabies from ancient times up to the present is undertaken. An attempt is made to trace parallel between the concept of the main cause of rabies in a certain period and the kind of treatment utilized. The ancient Greek goddess Artemis was considered to be a healer of rabies; they already identified wound cauterization. People of the first century A.D. knew of the infection deriving from the saliva of a rabid dog and called it virus (in Latin). During medieval times when a magical and religious concept regarding health was prevalent, the principal protector was called St. Humbert. During the Renaissance many experiments were carried out and new information on the disease was obtained, both were basic in opening the way for new findings in the future. At that time the miasmatic and contagious theories were predominant. Pasteur strongly objected to the idea of the spontaneity of rabies. At the end of the XIXth. century and based on microbial discoveries, Pasteur brought about a great scientific revolution as regards the possibility of treating rabies by using a vaccine. At the present time, vaccines are of the nervous type or not, and the recommended dose varies. A large-number of studies on vaccination have been undertaken. In Latin America the most used are those by Fuenzalida and Palacios. At present, WHO recommends the vaccine made by cell culture.
本文对从古至今人类狂犬病的治疗进行了历史回顾。试图追溯特定时期狂犬病主要病因的概念与所采用治疗方法之间的相似之处。古希腊女神阿尔忒弥斯被认为是狂犬病的治疗者;他们已经确定了伤口烧灼法。公元一世纪的人们知道狂犬病狗的唾液会导致感染,并将其称为病毒(拉丁语)。在中世纪,当关于健康的神奇和宗教观念盛行时,主要的保护者被称为圣洪贝特。在文艺复兴时期,人们进行了许多实验并获得了关于该疾病的新信息,这两者都为未来的新发现奠定了基础。当时,瘴气和传染理论占主导地位。巴斯德强烈反对狂犬病自然发生的观点。在19世纪末,基于微生物学的发现,巴斯德在狂犬病治疗可能性方面引发了一场伟大的科学革命,即使用疫苗治疗。目前,疫苗有神经组织疫苗和非神经组织疫苗,推荐剂量也有所不同。已经开展了大量关于疫苗接种的研究。在拉丁美洲,最常用的是富恩扎利达和帕拉西奥斯研发的疫苗。目前,世界卫生组织推荐使用细胞培养疫苗。