Babu P G, Ishida T, Nesadoss J, John T J
Department of Virology and Microbiology, Christian Medical College Hospital, Vellore, India.
Scand J Infect Dis. 1995;27(2):105-8. doi: 10.3109/00365549509018988.
This retrospective study was designed to determine the relationship between human T-lymphotropic virus (HTLV) type-I/II infection and human immunodeficiency virus (HIV) infection among sexually promiscuous persons in southern India. Stored sera collected between 1986 and 1993 from 822 male and 488 female patients attending clinics for sexually transmitted diseases (STD), for the purpose of HIV serosurveillance, were used. They comprised 376 HIV-positive sera and 934 HIV-negative sera. They were screened for HTLV-I/II antibody by a particle agglutination test and repeatedly reactive sera were confirmed by an immunofluorescence test and a western blot test. Five (2.4%) of 212 HIV-seropositive men were confirmed positive for HTLV-I/II antibody, while none of the 610 HIV-seronegative men were positive; the difference in prevalence between HIV-seropositive and seronegative men was statistically significant (p < 0.001). Nine (5.5%) of 164 HIV-seropositive women and 3 (0.9%) of 324 HIV-seronegative women were positive for HLTV-I/II antibody (p < 0.005). All HIV-seropositives taken together, had a significantly higher prevalence of HTLV-I/II (3.7%; 14/376) compared with HIV seronegatives (0.3%; 3/934; p < 0.001). Thus, in southern India, HTLV infection, like HIV infection, is sexually transmitted, though less effectively.
这项回顾性研究旨在确定印度南部性乱者中人类嗜T淋巴细胞病毒（HTLV）I/II型感染与人类免疫缺陷病毒（HIV）感染之间的关系。使用了1986年至1993年间从822名男性和488名女性性传播疾病（STD）门诊患者中收集的储存血清，用于HIV血清学监测。其中包括376份HIV阳性血清和934份HIV阴性血清。通过颗粒凝集试验对其进行HTLV-I/II抗体筛查，对反复呈反应性的血清通过免疫荧光试验和蛋白质印迹试验进行确认。212名HIV血清阳性男性中有5名（2.4%）被确认为HTLV-I/II抗体阳性，而610名HIV血清阴性男性中无一例阳性；HIV血清阳性和血清阴性男性之间的患病率差异具有统计学意义（p<0.001）。164名HIV血清阳性女性中有9名（5.5%）和324名HIV血清阴性女性中有3名（0.9%）HLTV-I/II抗体呈阳性（p<0.005）。所有HIV血清阳性者中HTLV-I/II的患病率（3.7%；14/376）显著高于HIV血清阴性者（0.3%；3/934；p<0.001）。因此，在印度南部，HTLV感染与HIV感染一样，是通过性传播的，尽管传播效率较低。
