el-Shazly M, Okello D O, Kawooya M G
Makerere Medical School, Faculty of Medicine, Makerere University, Kampala, Uganda.
Trop Doct. 1995 Jul;25(3):128-30. doi: 10.1177/004947559502500314.
A study of 41 clinically diagnosed cases of possible tropical splenomegaly syndrome (TSS) was undertaken in Mulago Hospital, Kampala, Uganda, to determine the appropriateness of liver ultrasonography in confirming a diagnosis of TSS. Definitive diagnosis of TSS was made on liver biopsy in 35 (85%) cases. Abdominal ultrasound showed that 30 of the confirmed cases of TSS had normal liver echo-texture and portal vein diameter, and five had abnormally increased liver echo-texture. The combination of massive splenomegaly and hepatomegaly, together with normal ultrasound features of the liver was highly suggestive of TSS. The sensitivity of this criterion was 86% and the specificity was 83%. This non-invasive approach to the diagnosis of TSS is associated with less hazards than liver biopsy, and a normal echogram could be used to make the diagnosis in over 80% of cases, in the field where histopathology may be lacking.
在乌干达坎帕拉的穆拉戈医院，对41例临床诊断为可能患有热带脾肿大综合征（TSS）的病例进行了研究，以确定肝脏超声检查在确诊TSS方面的适用性。35例（85%）通过肝活检确诊为TSS。腹部超声显示，30例确诊的TSS病例肝脏回声纹理和门静脉直径正常，5例肝脏回声纹理异常增加。巨大脾肿大和肝肿大，以及肝脏超声特征正常，高度提示TSS。该标准的敏感性为86%，特异性为83%。这种诊断TSS的非侵入性方法比肝活检风险更小，在缺乏组织病理学检查的情况下，超过80%的病例可通过正常的超声心动图进行诊断。
