Peng D H, Shi L
Department of Pharmacology, Pharmaceutical College, China Pharmaceutical University, Nanjing.
Yao Xue Xue Bao. 1995;30(5):343-6.
3,4-Dihydroxyacetophenone (DHAP) is one of the constituents of Ilex pubescence Hook. et Arn. var. glaber Chang. The effects of DHAP on the composition of blood platelet membrane in aged rats was examined. No change of total lipid and cholesterol contents was observed in aged rats. While a slight but significant decrease of phospholipid in platelet membrane was found, which lead to diminution of the ratio of phospholipid to cholesterol. The contents of phosphatidylethanolamine and phosphatidylcholine decreased markedly by as less as 23.0% and 19%, respectively, compared with the young group. Whereas the degree of reduction of phospholipid, the ratio of phospholipid to cholesterol, phosphatidylethanolamine and phosphatidylcholine were significantly lightened after irrigation with DHAP 100 mg.kg-1 for 10 weeks. In the treatment group, the values of phosphatidylethanolamine and phosphatidylcholine of platelet membrane were reduced by 8.0% and 10.5%, respectively, vs the group of aged rats. It is concluded that reduced phospholipid hydrolysis is involved in mediating DHAP inhibition of platelet function.
3,4-二羟基苯乙酮（DHAP）是毛冬青变种秃毛冬青的成分之一。研究了DHAP对老年大鼠血小板膜成分的影响。老年大鼠的总脂质和胆固醇含量未观察到变化。虽然发现血小板膜中的磷脂略有但显著减少，这导致磷脂与胆固醇的比例降低。与年轻组相比，磷脂酰乙醇胺和磷脂酰胆碱的含量分别显著降低了23.0%和19%。而在用100mg.kg-1的DHAP灌胃10周后，磷脂、磷脂与胆固醇的比例、磷脂酰乙醇胺和磷脂酰胆碱的降低程度明显减轻。在治疗组中，与老年大鼠组相比，血小板膜中磷脂酰乙醇胺和磷脂酰胆碱的值分别降低了8.0%和10.5%。得出结论，磷脂水解减少参与介导DHAP对血小板功能的抑制。
